FP630 : What drives post LASIK ectasia beyond topography

Dr. Natasha Pahuja (P16722)

Despite the prevalence of post LASIK ectasia (PLE) the aetiopathological factors associated with it are under explored.The current study investigated the association between ocular surface disease index (OSDI) scores, corneal dendritic cell density (DCD) and tear inflammatory factors in post-LASIK ectasia. The study included age, sex and post- LASIK duration matched 7 (14 eyes) post-LASIK controls (PLC) and 6 (12 eyes) post- LASIK ectasia (PLE) subjects. BAD-D scores, OSDI scores and corneal dendritic cell density were significantly (P<0.05) higher in patients with PLE compared to PLC. The fold difference of CCL2/MCP1 (3.4±0.6) was found to be significantly (P<0.05) higher in the PLE cohorts. The data indicates that one of the pathways of post-LASIK ectasia resulting in aberrant corneal curvature is associated with an inflammatory response dependent on corneal dendritic cells which can be used as clinical screening tool pre operatively.

 

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